Active Ingredient: Imidacloprid | Type: Spot-on | Active For: 4 weeks | Prescription Required: No | Cat Weight: 2-5 pounds, 5-9 pounds, 9+ pounds

In our experience, Advantage Spot-On Flea Treatment may be the best flea medicine for cats without a vet prescription. It contains two active ingredients, Imidacloprid and Pyriproxyfen, that target fleas at different life cycle stages and prevent future infestations. This medicine should be administered monthly and will start killing fleas within 12 hours.

Advantage flea treatment works by eliminating fleas via contact, which means there’s no chance for the flea to bite your cat. This is especially important for cats suffering from flea allergy dermatitis because the flea saliva triggers intense itching.

What We Like:
• One of the most effective options
• Works on contact
• Available in a range of pack sizes
• Available without a prescription

What We Don’t Like:
• Doesn’t prevent or treat ticks or other parasites
• Strong smelling liquid
• Skin irritation may occur in a small number of cats

Active Ingredient: Selamectin and Sarolaner | Type: Spot-on 
Active For: 4 weeks | Prescription Required: No | Cat Weight: 2.8-5.5 pounds, 5.6-11 pounds, 11.1-22 pounds

Revolution Plus Topical Solution is the perfect way to protect your furry friend from fleas, roundworms, hookworms, ear mites, ticks, and heartworms. Your cat will surely appreciate this added layer of protection, especially if they love spending time outside and are at a higher risk of getting plagued by these harmful parasites.

One of the great things about this product is that it’s easy to apply, even if your cat is nervous. The pipettes contain enough liquid for a quick and hassle-free application. Give your cat the gift of protection with Revolution Plus Topical Solution.

Note: The Revolution Plus requires a prescription, and weighing your cat beforehand is recommended to ensure the correct dosage.

What We Like:
• Broad acting
• Suitable for kittens from 8 weeks
• Fast drying

What We Don’t Like:
• Prescription required
• Costly

Active Ingredient: Nitenpyram | Type: Tablet | Active For: One day | Prescription Required: No | Cat Weight: 2-25 pounds

Capstar is a quick-acting flea control medication that contains Nytenpyram as its active ingredient. It starts working within 30 minutes of intake and kills adult fleas efficiently. You can give it to your cat once daily as necessary. It comes in packets of 6 or 12 and doesn't require a prescription. 

There are two ways to give this medicine to your cat- directly in the mouth or hidden in food. Although you can crush the tablet, it may taste bitter, so it works better when given whole. 

Note: Capstar kills adult fleas quickly, but it needs to be used for several days as the larvae hatch. 

What We Like:
• Fleas start falling off within an hour
• Available over the counter

What We Don’t Like:
• Only effective on adult fleas
• Requires repeated administration

Active ingredient: Spinosad | Type: Tablet | Active For: 4 weeks | Prescription Required: Yes | Cat Weight: 4.1-6 pounds, 6.1-12 pounds, 12.1-24 pounds

When multiple pets are in the house, you have to make sure that all of them are up-to-date with their parasite prevention regimen. Fleas can quickly spread from one pet to another, with dogs usually catching them from cats. If left untreated, fleas can wreak havoc in your home.

Comfortis Chewable Tablets are suitable for dogs and cats aged 14 weeks or older. They work quickly and can eliminate fleas less than an hour after consumption. Administer the tablets once a month alongside food for optimal effectiveness.

What We Like:
• An excellent option for multiple pet households
• Small tablet size

What We Don’t Like:
• Only effective against fleas
• Not suitable for smaller kittens (under 14 weeks)
• Strong chemical odor

Active ingredient: Fluralaner | Type: Spot-on | Active For: 12 weeks | Prescription Required: Yes | Cat Weight: 2.6-6.2 pounds, 6.2-13.8 pounds, 13.8+ pounds

Bravecto is a widely recognized and trusted product that kills and prevents fleas and effectively combats ticks. It is proven to eliminate all fleas on the cat within eight hours of application and all ticks within twelve hours. 

The “twist and use” design eliminates the need to fumble with removing the cap, making it one of the simplest spot-on treatments to administer, particularly for cats who aren't fond of them.

What makes Bravecto so attractive is that it provides an astonishing three months of flea prevention. This is perfect for pet parents who struggle to keep up with monthly applications. It is available in a variety of sizes and can be purchased as either a one or two-pack. 

What We Like:
• 12-week protection against fleas
• Two months of protection against ticks

What We Don’t Like:
• Not suitable for cats less than six months old

Active ingredient: Fipronil and (S)methoprene | Type: Spot-on | Active For: 4 weeks | Prescription Required: No | Cat Weight: One size

Frontline Plus Flea and Tick Spot Treatment is a preventive measure against fleas and a killer of ticks and chewing lice. It is effective against both adult fleas and flea eggs, which helps to prevent re-infestation. This spot-on treatment is suitable for kittens as young as 8 weeks old and weighing at least 1.5 pounds. Even indoor cats can get fleas and ticks, so it is wise to keep their prevention up to date.

The active ingredients in this spot-on treatment disrupt the flea life cycle, preventing new infestations from developing. A single application protects cats against fleas and ticks for a whole month. 

What We Like:
• Easy application
• Dual protection against both ticks and fleas
• Safe for those kittens who are at least eight weeks old
• Available in 3, 6, 8 and 12 pack

What We Don’t Like:
• No worm prevention
• Skin irritation is a possible side effect

Active ingredient: Pyrethrins, Piperonyl Butoxide | Type:  Shampoo | Active For: 1 week | Prescription Required: No | Cat Weight: 1.5+ pounds

Advantage Flea and Tick Shampoo unscented formula produces a good lather and can be used on kittens that are twelve weeks or older. If you have a sensitive kitty who doesn't respond well to tablets or spot-on treatments, this shampoo may be the perfect solution. 

Bear in mind that using this shampoo alone won't completely eradicate fleas and ticks from your environment. You must treat your home and yard to eliminate these parasites effectively. 

Note: When bathing a younger kitten, remember they have low body fat levels and can get cold quickly. So, keep the bath brief and dry them thoroughly with a towel.

What We Like:
• Effective alternative to the traditional tablets or spot-on treatment

What We Don’t Like:
• Contains Pyrethrin, which is highly toxic to cats if ingested
• Must be used no more than once every 7 days
• Most cats dislike taking baths

Active ingredient: Selamectin | Type: Spot-on | Active For: 1 month | Prescription Required: No | Cat Weight: 5.1-15 pounds, 15.1-22 pounds

Revolt Topical Solution for Cats is a highly effective flea treatment that contains Selamectin. This solution not only treats fleas but also prevents heartworms and treats ear mites, hookworms, and roundworms.

Like other spot-on treatments, you must apply Revolt to the skin without rubbing. To ensure its effectiveness, avoid bathing your pet for at least 24 hours after using the product. This treatment not only kills fleas but also prevents the hatching of eggs, providing more comprehensive control.

What We Like:
• Broad spectrum
• Available in several sizes

What We Don’t Like:
• Prescription required
• Costly

Active ingredient: Imidacloprid and Flumethrin | Type: Collar | Active For:  8 months | Prescription Required:  Yes | Cat Weight: One size

Seresto Flea and Tick Collar is one of the most effective treatments available. Unlike tablets or spot-on treatments, flea collars are generally well-tolerated by felines. The collar starts working within 24 hours, providing continuous protection for up to eight months. 

Some cats may start losing their fur under the collar; consult your vet for guidance

What We Like:
• Eight months of flea and tick prevention
• Great solution if your cat suffers from flea allergy

What We Don’t Like:
• Not effective on parasites other than fleas and ticks

Active Ingredient: Fluralaner, Moxidectin | Type: Spot-on | Active For: 2 months  | Prescription Required: Yes | Cat Weight: 2.6-6.2 pounds, 6.2-13.8 pounds, 13.9-27.5 pounds

Bravecto Plus Topical Solution treats fleas and is an excellent option for coping with parasites like intestinal worms and heartworms. However, it’s not an over-the-counter medication, so you’ll need to get a prescription from your veterinarian. 

The medication comes in three sizes, and you can easily apply it using a pipette on the skin between your cat’s shoulder blades. Most cats don't mind it, but if your kitty has difficulties, you can always ask your vet for help.

Note: Suitable for cats older than six months

What We Like:
• Broad spectrum
• Vet-approved
• Two months of flea and tick prevention

What We Don’t Like:
• Not suitable for cats younger than six months
• Prescription required