It was quite a difficult task for the director of The Killing Fields to find an actor that would be able to emote the horror of witnessing the tragedies of the Khmer Rouge during the Cambodian genocide. However, fate brought him to the gynaecologist Haing S. Ngor—a man who survived three terms in Cambodian prison camps, using his medical knowledge to keep himself alive by eating beetles, termites, scorpions, and rats.

Ngor is one of the only two non-professional actors to win an Academy Award in an acting category.

Turns out, when Ermey was a teenager, he got arrested twice for criminal mischief. The judge told him that he could either go to jail or join the Marine Corps. After serving for 11 years, he became a technical advisor for the movie industry. He took on this position with the goal to show filmmakers that he should be starring in their movies. As you can see, his plan worked out quite perfectly. Ermey persuaded Kubrick to cast him in Full Metal Jacket by making a homemade audition tape capturing him screaming insults.

Avu and Swati Chokalingam, who play Kelly's parents on The Office, are, in fact, Mindy Kaling's real-life parents. In real life, Avu is an architect and Swati was an obstetrician/gynecologist.

Turns out, An, who plays the nurse Bokhee on Grey's Anatomy, is a scrub nurse in real life and continues working with open-heart surgeries in Los Angeles.

After seeing a commercial on a local Minneapolis TV channel, Abdi showed up to a casting call for background characters. Instead of that, he got offered one of the main roles.

Before entering the film industry, Abdi sold mobile phones at his brother's shop at a mall in Minneapolis and worked as a limousine driver and as a DJ.

Bautista is a retired professional wrestler, former mixed martial artist and bodybuilder. Even though Drax wasn't his first acting role, it was his first leading part in a massive blockbuster.

Russell was a Canadian-born American in World War II. In a demolition mishap, he lost both his hands and was given two hooks instead of them.

In 1945, Russell was featured in Diary of a Sergeant, an Army film about rehabilitating war veterans. After seeing the film, the director William Wyler offered him the role of Homer Parrish in The Best Years of Our Lives.

Russell is one of the only two non-professional actors to win an Academy Award in an acting category.

While Jamil was working as a writer at 3 Arts, her agents told her that the co-creator of Parks and Recreation, Michael Schur, was looking for a British actress for a new upcoming comedy series. After auditioning, Jamil got the role. Before the acting career, she was working as a model and a radio host.

Kravitz is an American singer-songwriter, multi-instrumentalist, and record producer who was invited to play the part of Katniss' creative stylist, Cinna, in the first two Hunger Games movies.

Rutherford worked as an IT technician. To make his performances as natural as possible, he was told that he'd simply be the team's IT guy while starring in a small part of the movie. Rutherford did not realize how much he was in the film until the premiere.

Trejo was a youth counselor that was brought in on the set of the action thriller Runaway Train to help a cast member with his substance problem. He got noticed by the director of the movie and the writer of the screenplay and was offered the role.

Vinnie Jones is a former professional footballer known for his "hard man" image on the field. His acting career began with Lock, Stock and Two Smoking Barrels and continued with other roles, usually those of fearsome demeanor and physical characters.

Before being offered the role, Cates was a daytime talk show guest where she discussed her battle with obesity and how it had affected her life. The screenwriter Peter Hedges noticed the woman and thought she'd be the perfect person to play the main character’s housebound mother in What’s Eating Gilbert Grape.

Before being chosen for the role, Aparicio was a schoolteacher. She is the first Indigenous American woman and the second Mexican woman to receive a Best Actress Oscar nomination.

Before being offered the role, Copley was working in the entertainment industry as a small-time producer. Copley was offered the role by his friend Neill Blomkamp, who was also the director of District 9.

Silva was a set dresser. He worked on Twin Peaks when the director David Lynch realized that Silva might have a place in the show. He asked Silva if he was an actor, Silva said yes, and the rest is history.

Styles is an English singer and songwriter, mostly known for being a part of one of the best-selling boy bands of all time called One Direction.

In 2017, Harry was chosen to play the role of a British soldier named Alex in Christopher Nolan's war film Dunkirk. Nolan said that Harry was chosen for the part not because of his fame, but "because he fit the part wonderfully and truly earned a seat at the table."

Davidson, a fashion model, was drunk at a party when someone came to him, gave him a number, and asked him to call if he'd like to be in a movie. And that's how Davidson got offered the role of the transgender woman Dil.

Shoukath and Fatima Ansari are Aziz Ansari's real-life parents as well as being his character's parents in the series.

Matuszak was an American football defensive end in the National Football League. In the 1980s, he started appearing in films and on television, often portraying football players. His most well-known role is the deformed captive Sloth in The Goonies.

Hill was an American politician and police officer. He was discovered when the director of the movie was looking for shooting locations in Detroit.

Golding was a show host when he was offered the role of Nick Young. The accountant that was working in the film’s Malaysian production office suggested Golding, who she had met a few years before.

Turns out, Brown arrived at a casting call for extras during preproduction on the 2000 film Finding Forrester. Instead of that, he was offered the leading role.

Brooks was an American physician. In 1975, he was the head of Oregon State Hospital—the place where One Flew Over the Cuckoo's Nest was filmed, and that's why he stars in the movie.

Miyavi is a Japanese guitarist, singer-songwriter, and record producer. In 2014, he was offered a role in the movie Unbroken by the director Angelina Jolie.

Björk is an Icelandic singer, songwriter, record producer, and DJ. Björk was asked to write and produce the musical score for the film Dancer in the Dark, and eventually was asked to play the leading role of Selma.

In 2015, the professional basketball player LeBron James was invited to play a comedy version of himself in the movie Trainwreck, and absolutely nailed it.

Hunter Schafer is an American fashion model and LGBTQ rights activist. Schafer has modelled for Dior, Miu Miu, Calvin Klein, Tommy Hilfiger, Coach, Vera Wang, Marc Jacobs, Versus Versace, Emilio Pucci and many other famous fashion houses.

In 2019, she was offered the role of Jules in HBO's Euphoria.

Sean Baker, the director of The Florida Project, spotted Vinaite's Instagram post and decided to approach her. Bria was offered the role, and after three weeks of acting classes, the filming began.

Attah was discovered by the director Cary Fukunaga in Ghana while skipping class to play soccer.

Stevens is an American Thoroughbred horse racing jockey who played the jockey George Woolf in 2003 movie 'Seabiscuit.'

The producer Frank Marshall and the film’s director, screenwriter and co-producer Gary Ross approached Stevens at the Santa Anita Park racetrack where they went for research. And even though Stevens turned them down at first, they managed to convince him to take the role.

Pearson had a tough childhood and when she was only 16 years old, she was convicted of second-degree murder after the shooting of a girl named Okia Toomer and was sentenced to two eight-year terms. After six and a half years, she was released from prison.

Pearson was offered the role on The Wire after she met Michael K. Williams, who played Omar Little on the show, and was invited to come to the set, where she met the writers and the producers.

Lane was at the beach in Miami when Andrea Arnold, the writer/director of American Honey, approached her and offered her the role of Star. Before becoming an actress, Lane worked as a waitress at a restaurant.

Garnett is an American former professional basketball player. Garnett was approached by the Safdie brothers, the directors of the thriller, and was offered the part.

Horn was participating in Jeopardy! Kids Week when he was noticed by the producers and offered the role of Oskar Schell in the 2011 movie called Extremely Loud & Incredibly Close.

The Safdie brothers, who are the directors of the movie Heaven Knows What, scouted her off the street while working on another film. The movie was based on Holmes' unpublished memoir.

Lee Daniels, the director of Precious, wanted Carey to play the character of Ms. Weiss, a social worker, since he was extremely impressed by her performance in 2008's Tennessee.